Metformin Use in Adolescents: Old and New Therapeutic Perspectives
نویسندگان
چکیده
Metformin (1,1-dimethylbiguanide) is the most widely used drug to treat type 2 diabetes, and is one of only two oral antidiabetic drugs on the World Health Organization (WHO) list of essential medicines [1]. Its history can be traced back to the use of Galega officinalis as a herbal medicine in medieval Europe. Its name derives from gale (milk) and ega (to bring on), as Galega has been used as a galactogogue in small domestic animals (hence the name “Goat’s rue”). Studies in the late 1800s indicated that Galega officinalis was rich in guanidine and in 1918 guanidine was shown to possess hypoglycaemic activity in animals. Jean Sterne was the first to investigate dimethylbiguanide (Metformin) for clinical development and proposed the name ‘Glucophage’ (glucose eater) and published his results in 1957 [2-4].
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